产品名称
GDF11 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10220
Human Swissprot No.
O95390
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95390/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14561
Mouse Swissprot No.
Q9Z1W4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z1W4
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z217
免疫原
Synthesized peptide derived from human GDF11 AA range: 217-267
特异性
This antibody detects endogenous levels of GDF11 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016],
组织表达
In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme.
功能
function:Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
