产品名称
FOXM1 Rabbit Polyclonal Antibody
基因名称
FOXM1 FKHL16 HFH11 MPP2 WIN
蛋白名称
Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q08050
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q08050/entry
Mouse Swissprot No.
O08696
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08696
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P97691
免疫原
Synthesized peptide derived from human protein . at AA range: 190-270
特异性
FOXM1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],
组织表达
Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.
功能
alternative products:Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3, found in rat, does not seem to exist in human,developmental stage:Embryonic expression pattern: liver, lung, intestine, kidney, urinary tract; adult expression pattern: intestine, colon, testis and thymus.,domain:Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4.,function:Transcriptional activatory factor. May play a role in the control of cell proliferation.,induction:Induced during liver regeneration and oxidative stress.,PTM:Phosphorylated in M (mitotic) phase.,similarity:Contains 1 fork-head DNA-binding domain.,tissue specificity:Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
