产品名称
PO2F3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/25833
Human Swissprot No.
Q9UKI9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UKI9/entry
Mouse Swissprot No.
P31362
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P31362
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P42571
免疫原
Synthesized peptide derived from human PO2F3 AA range: 240-290
特异性
This antibody detects endogenous levels of PO2F3 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],
组织表达
Specifically expressed in epidermis and cultured keratinocytes.
功能
function:Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.,similarity:Belongs to the POU transcription factor family. Class-2 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,tissue specificity:Specifically expressed in epidermis and cultured keratinocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
