产品名称
BNC1 Rabbit Polyclonal Antibody
蛋白名称
Zinc finger protein basonuclin-1
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q01954
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q01954/entry
Mouse Swissprot No.
O35914
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35914
免疫原
Synthesized peptide derived from human protein . at AA range: 10-90
特异性
BNC1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. Alternative splicing of this gene results in multiple transcript variants, and multiple polyadenylation sites are indicated.[provided by RefSeq, Jul 2014],
组织表达
In epidermis, primarily detected in cells of the basal or immediately suprabasal layers (at protein level) (PubMed:16891417). In hair follicles, mainly expressed in the outer root sheath (at protein level) (PubMed:8034748). Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart (PubMed:9687312). Expressed in the ovary, notably in oocytes (PubMed:30010909).
细胞定位
Nucleus . Cytoplasm . Nucleus, nucleoplasm . Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids. .
功能
function:Likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. May play a role in the differentiation of spermatozoa and oocytes.,PTM:Phosphorylation on Ser-537 and Ser-541 leads to cytoplasmic localization.,similarity:Contains 6 C2H2-type zinc fingers.,subcellular location:Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids.,tissue specificity:Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
