产品名称
NKD2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/85409
Human Swissprot No.
Q969F2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q969F2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/72293
Mouse Swissprot No.
Q8VE28
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VE28
免疫原
Synthesized peptide derived from human NKD2 AA range: 311-361
特异性
This antibody detects endogenous levels of NKD2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012],
组织表达
Expressed in kidney, lung, pancreas and spleen.
细胞定位
Cell membrane . Cytoplasm . Cytoplasmic vesicle .
功能
developmental stage:Expressed in fetal kidney and lung.,function:Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.,similarity:Belongs to the NKD family.,similarity:Contains 1 EF-hand domain.,subunit:Interacts with DVL1, DVL2, DVL3 and PPP2R3A (By similarity). Interacts with TGFA.,tissue specificity:Expressed in kidney, lung, pancreas and spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
