产品名称
ASCC3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10973
Human Swissprot No.
Q8N3C0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N3C0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/77987
Mouse Swissprot No.
E9PZJ8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/E9PZJ8
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/F1LPQ2
免疫原
Synthesized peptide derived from human ASCC3 AA range: 2053-2103
特异性
This antibody detects endogenous levels of ASCC3 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
细胞定位
Nucleus . Nucleus speckle . Cytoplasm, cytosol . Colocalizes with ALKBH3 and ASCC2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. .
功能
function:Enhances NF-kappa-B, SRF and AP1 transactivation.,similarity:Belongs to the helicase family.,similarity:Contains 2 helicase ATP-binding domains.,similarity:Contains 2 helicase C-terminal domains.,similarity:Contains 3 SEC63 domains.,subunit:Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
