产品名称
R9BP Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/388531
Human Swissprot No.
Q6ZS82
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6ZS82/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/243923
Mouse Swissprot No.
Q148R9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q148R9
免疫原
Synthesized peptide derived from human R9BP AA range: 138-188
特异性
This antibody detects endogenous levels of R9BP at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. Mutations in this gene are associated with prolonged electroretinal response suppression (PERRS), also known as bradyopsia. [provided by RefSeq, Mar 2010],
细胞定位
Membrane ; Single-pass type IV membrane protein .
功能
disease:Defects in RGS9BP are a cause of prolonged electroretinal response suppression (PERRS) [MIM:608415]; also known as bradyopsia. PERRS is characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones.,function:Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates to the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation.,similarity:Belongs to the RGS7BP/RGS9BP family.,subunit:Specifically interacts with isoform RGS9-1 of RGS9. Component of the RGS9-1-Gbeta5 complex composed of RGS9-1, Gbeta5 (GNB5) and RGS9BP.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
