产品名称
PIGO Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84720
Human Swissprot No.
Q8TEQ8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TEQ8/entry
Mouse Swissprot No.
Q9JJI6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJI6
免疫原
Synthesized peptide derived from human PIGO AA range: 950-1000
特异性
This antibody detects endogenous levels of PIGO at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011],
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
alternative products:Additional isoforms seem to exist,function:Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond.,pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.,similarity:Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.,subunit:Forms a complex with PIGF. PIGF is required to stabilize PIGO.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
