产品名称
SRGP2 Rabbit Polyclonal Antibody
基因名称
SRGAP2 ARHGAP34 FNBP2 KIAA0456 SRGAP2A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23380
Human Swissprot No.
O75044
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75044/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14270
Mouse Swissprot No.
Q91Z67
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91Z67
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/D4A208
免疫原
Synthesized peptide derived from human SRGP2 AA range: 476-526
特异性
This antibody detects endogenous levels of SRGP2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014],
细胞定位
Cell membrane . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic density . Cell junction, synapse, postsynaptic cell membrane . Cell projection, lamellipodium . Cytoplasmic vesicle, phagosome . Nucleus . Cytoplasm, cytosol . Recruited to actin-rich phagosomes during phagocytosis (By similarity). Translocates from nucleus to cytoplasm during development (By similarity). .
功能
function:Putative GTPase-activating protein for Rho family small GTPases.,similarity:Contains 1 FCH domain.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,subunit:Probably interacts with ROBO1.,tissue specificity:Expression at low levels in placenta, kidney, and ovary, and little or no expression in all other tissues tested.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
