产品名称
FRPD2 Rabbit Polyclonal Antibody
基因名称
FRMPD2 PDZD5C PDZK4 PDZK5C
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/143162
Human Swissprot No.
Q68DX3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q68DX3/entry
免疫原
Synthesized peptide derived from human FRPD2 AA range: 1161-1211
特异性
This antibody detects endogenous levels of FRPD2 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009],
组织表达
Expressed in epithelial cells.
细胞定位
Cytoplasm . Basolateral cell membrane . Cell junction, tight junction . Colocalizes with CTNNB1, CDH1 and PKP4 at the basolateral membrane. Colocalizes with TJP1 at tight junctions. Its recruitment to cell-cell contacts requires CDH1.
功能
caution:Could be the product of a pseudogene. This is the product of related genes or pseudogenes located in a region of chromosome 10q which contains a segmental duplication resulting in three nearly identical regions.,similarity:Contains 1 FERM domain.,similarity:Contains 1 KIND domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 2 PDZ (DHR) domains.,similarity:Contains 3 PDZ (DHR) domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
