产品名称
BEX2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84707
Human Swissprot No.
Q9BXY8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BXY8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12069
Mouse Swissprot No.
Q9WTZ8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WTZ8
Rat Gene Link
https://www.uniprot.org/uniprot/363498
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q3MKQ1
免疫原
Synthesized peptide derived from human BEX2 AA range: 28-78
特异性
This antibody detects endogenous levels of BEX2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009],
组织表达
Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Widely expressed in breast cancer cell lines.
细胞定位
Cytoplasm . Nucleus .
功能
caution:Was named BEX1 by some authors.,similarity:Belongs to the BEX family.,subunit:Interacts with OMP (By similarity). Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2.,tissue specificity:Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
