产品名称
DOXA1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/90527
Human Swissprot No.
Q1HG43
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q1HG43/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/213696
Mouse Swissprot No.
Q8VE49
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VE49
免疫原
Synthesized peptide derived from human DOXA1 AA range: 24-74
特异性
This antibody detects endogenous levels of DOXA1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013],
组织表达
Specifically expressed in thyroid gland. Also detected in esophagus.
细胞定位
Membrane ; Multi-pass membrane protein .
功能
function:May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1.,similarity:Belongs to the DUOXA family.,subunit:May interact with NUMB.,tissue specificity:Specifically expressed in thyroid gland. Also detected in esophagus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
