产品名称
C1GLT Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/56913
Human Swissprot No.
Q9NS00
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NS00/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/94192
Mouse Swissprot No.
Q9JJ06
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJ06
Rat Gene Link
https://www.uniprot.org/uniprot/65044
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJ05
免疫原
Synthesized peptide derived from human C1GLT AA range: 102-152
特异性
This antibody detects endogenous levels of C1GLT at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010],
组织表达
Widely expressed. Highly expressed in kidney, heart, placenta and liver.
细胞定位
Membrane ; Single-pass type II membrane protein .
功能
catalytic activity:UDP-galactose + glycoprotein N-acetyl-D-galactosamine = UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine.,cofactor:Magnesium.,disease:Defects in C1GALT1 may be a cause of susceptibility to IgA nephropathy (IgAN). IgAN is the most common primary glomerulonephritis, which is partly due to aberrant or incomplete galactosylation of IgA1 molecules.,function:Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.,online information:Core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.,subunit:Homodimer; disulfide-linked (By similarity). Interacts with the C1GALT1C1 chaperone; required for galactosyltransferase activity.,tissue specificity:Widely expressed. Highly expressed in kidney, heart, placenta and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
