产品名称
KCNH4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23415
Human Swissprot No.
Q9UQ05
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UQ05/entry
Rat Gene Link
https://www.uniprot.org/uniprot/114032
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R1T9
免疫原
Synthesized peptide derived from human KCNH4.AA range:180-250
特异性
This antibody detects endogenous levels of KCNH4 at Human/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system. [provided by RefSeq, Jul 2008],
组织表达
Detected only in brain, in particular in the telencephalon. Detected in putamen and caudate nucleus, and at lower levels in cerebral cortex, occipital and hippocampus.
细胞定位
Membrane; Multi-pass membrane protein.
功能
domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly.,similarity:Belongs to the potassium channel family. H (Eag) subfamily.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.,tissue specificity:Detected only in brain, in particular in the telencephalon. Detected in putamen and caudate nucleus, and at lower levels in cerebral cortex, occipital and hippocampus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
