产品名称
ATL4 Rabbit Polyclonal Antibody
基因名称
ADAMTSL4 TSRC1 PP1396 UNQ2803/PRO34012
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54507
Human Swissprot No.
Q6UY14
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6UY14/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/229595
Mouse Swissprot No.
Q80T21
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80T21
Rat Gene Link
https://www.uniprot.org/uniprot/310670
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4FZU4
免疫原
Synthesized peptide derived from human ATL4 AA range: 78-128
特异性
This antibody detects endogenous levels of ATL4 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Sep 2014],
组织表达
Expressed in colon, heart, leukocyte, liver, lung, skeletal muscle, spleen, testis and placenta. Weaker expression in bone marrow, brain tissue, kidney and pancreas. Expression studies in fetal tissues reveal strong expression in heart, kidney, liver, lung and skeletal muscle, but weaker expression in fetal brain and skin.
细胞定位
Secreted, extracellular space, extracellular matrix . Colocalizes with FMN1 microfibrils in the eye ECM.
功能
caution:Although similar to members of the ADAMTS family, it lacks the metalloprotease and disintegrin-like domains which are typical of that family.,function:Positive regulation of apoptosis.,similarity:Contains 1 PLAC domain.,similarity:Contains 6 TSP type-1 domains.,subunit:Interacts with CTSB.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
