产品名称
MRP Rabbit Polyclonal Antibody
蛋白名称
MARCKS-related protein (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P49006
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P49006/entry
Mouse Swissprot No.
P28667
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P28667
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q9EPH2
免疫原
Synthesized peptide derived from human protein . at AA range: 1-80
特异性
MRP Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
MARCKS like 1(MARCKSL1) Homo sapiens This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012],
组织表达
Brain,Epithelium,Muscle,
细胞定位
Cytoplasm, cytoskeleton . Cell membrane ; Lipid-anchor . Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin. Colocalizes with F-actin at the leading edge of migrating cells (By similarity). In prostate cancers, shows strong expression at apical and/or basal regions of the cell and also has weak cytoplasmic expression (PubMed:22751924). .
信号通路
Fc gamma R-mediated phagocytosis;
功能
function:May be involved in coupling the protein kinase C and calmodulin signal transduction systems.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MARCKS family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
