产品名称
CHP3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54997
Human Swissprot No.
Q96BS2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96BS2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/57816
Mouse Swissprot No.
Q9JKL5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JKL5
免疫原
Synthesized peptide derived from human CHP3 AA range: 20-70
特异性
This antibody detects endogenous levels of CHP3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
细胞定位
Nucleus . Cytoplasm . Membrane ; Lipid-anchor . Cell membrane . Cell projection, lamellipodium . Cell projection, ruffle membrane . Colocalizes with SLC9A1 at the plasma membrane. .
功能
caution:It is uncertain whether Met-1 or Met-54 is the initiator.,cofactor:Binds calcium.,developmental stage:Strongly up-regulated in K562 cells treated by PMA to promote megakaryocytic differentiation, but not when treated by DMSO to promote granulocytic differentiation or by hemin to promote erythroid differentiation (at protein level).,function:Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation.,similarity:Contains 1 EF-hand domain.,subunit:Interacts with Sodium/hydrogen exchanger 1 (SLC9A1).,tissue specificity:Abundantly expressed in heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
