BD-PT6820

FACR1 Rabbit Polyclonal Antibody

常规抗体

FAR1 MLSTD2 UNQ2423/PRO4981

FACR1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

84188

https://www.uniprot.org/uniprot/84188

Q8WVX9

https://www.uniprot.org/uniprotkb/Q8WVX9/entry

67420

https://www.uniprot.org/uniprot/67420

Q922J9

https://www.uniprot.org/uniprotkb/Q922J9

293173

https://www.uniprot.org/uniprot/293173

Q66H50

https://www.uniprot.org/uniprotkb/Q66H50

Synthesized peptide derived from human FACR1 AA range: 135-185

This antibody detects endogenous levels of FACR1 at Human/Mouse/Rat

WB 1：500-2000

57kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015],

Peroxisome membrane ; Single-pass membrane protein .

catalytic activity:Fatty acyl-CoA + 2 NADPH = fatty alcohol + 2 NADP(+).,function:Catalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols.,similarity:Belongs to the fatty acyl-CoA reductase family.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.