产品名称
NMNA3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/349565
Human Swissprot No.
Q96T66
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96T66/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/74080
Mouse Swissprot No.
Q99JR6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99JR6
免疫原
Synthesized peptide derived from human NMNA3 AA range: 97-147
特异性
This antibody detects endogenous levels of NMNA3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],
组织表达
Expressed in lung and spleen with lower levels in placenta and kidney.
功能
catalytic activity:ATP + nicotinamide ribonucleotide = diphosphate + NAD(+).,catalytic activity:ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD(+).,cofactor:Divalent metal cations. Magnesium confers the highest activity.,enzyme regulation:Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate (Nap4AD).,function:Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury.,pathway:Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide ribonucleotide: step 1/1.,similarity:Belongs to the eukaryotic NMN adenylyltransferase family.,subunit:Homotetramer.,tissue specificity:Expressed in lung and spleen with lower levels in placenta and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
