产品名称
CMPK2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/129607
Human Swissprot No.
Q5EBM0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5EBM0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22169
Mouse Swissprot No.
Q3U5Q7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3U5Q7
免疫原
Synthesized peptide derived from human CMPK2 AA range: 57-107
特异性
This antibody detects endogenous levels of CMPK2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012],
组织表达
Among all investigated tumors, leukemia cells show the most abundant expression.
功能
catalytic activity:ATP + (d)CMP = ADP + (d)CDP.,function:May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs.,similarity:Belongs to the thymidylate kinase family.,tissue specificity:Among all investigated tumors, leukemia cells show the most abundant expression.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
