产品名称
MSH5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4439
Human Swissprot No.
O43196
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43196/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/17687
Mouse Swissprot No.
Q9QUM7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QUM7
Rat Gene Link
https://www.uniprot.org/uniprot/294252
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6MG62
免疫原
Synthesized peptide derived from human MSH5 AA range: 13-63
特异性
This antibody detects endogenous levels of MSH5 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011],
组织表达
Widely expressed, with high levels in testis and ovary, including granulosa cells (PubMed:9740671, PubMed:28175301). Also expressed in fetal ovary and adrenal gland (PubMed:28175301).
细胞定位
synaptonemal complex,mismatch repair complex,
功能
function:Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis.,similarity:Belongs to the DNA mismatch repair mutS family.,subunit:Heterooligomer of MSH4 and MSH5. Interacts with HJURP.,tissue specificity:Ubiquitous, but highly expressed in testis, and thymus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
