产品名称
SMS1 Rabbit Polyclonal Antibody
基因名称
SGMS1 MOB SMS1 TMEM23
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/259230
Human Swissprot No.
Q86VZ5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86VZ5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/208449
Mouse Swissprot No.
Q8VCQ6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VCQ6
Rat Gene Link
https://www.uniprot.org/uniprot/353229
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TSX5
免疫原
Synthesized peptide derived from human SMS1 AA range: 156-206
特异性
This antibody detects endogenous levels of SMS1 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain. [provided by RefSeq, Jul 2008],
组织表达
Brain, heart, kidney, liver, muscle and stomach.
细胞定位
Golgi apparatus membrane ; Multi-pass membrane protein .
功能
catalytic activity:A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol.,enzyme regulation:Inhibited by bacterial PC-phospholipase C inhibitor D609.,function:Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Required for cell growth.,miscellaneous:Overexpression of the human protein in mouse causes increased non-HDL-sphingomyelin and non-HDL cholesterol levels, decreased HDL-sphingomyelin and HDL-cholesterol levels and increases lipoprotein atherogenic potential.,sequence caution:Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.,similarity:Belongs to the sphingomyelin synthase family.,similarity:Contains 1 SAM (sterile alpha motif) domain.,tissue specificity:Brain, heart, kidney, liver, muscle and stomach.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
