产品名称
MLXPL Rabbit Polyclonal Antibody
基因名称
MLXIPL BHLHD14 MIO WBSCR14
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/51085
Human Swissprot No.
Q9NP71
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NP71/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/58805
Mouse Swissprot No.
Q99MZ3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99MZ3
Rat Gene Link
https://www.uniprot.org/uniprot/171078
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VIP2
免疫原
Synthesized peptide derived from human MLXPL AA range: 303-353
特异性
This antibody detects endogenous levels of MLXPL at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
组织表达
Expressed in liver, heart, kidney, cerebellum and intestinal tissues.
功能
disease:Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Binds DNA as a heterodimer with TCFL4/MLX.,tissue specificity:Expressed in liver, heart, kidney, cerebellum and intestinal tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
