产品名称
ERP29 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10961
Human Swissprot No.
P30040
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P30040/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67397
Mouse Swissprot No.
P57759
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P57759
Rat Gene Link
https://www.uniprot.org/uniprot/117030
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P52555
免疫原
Synthesized peptide derived from human ERP29 AA range: 141-191
特异性
This antibody detects endogenous levels of ERP29 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitous. Mostly expressed in secretory tissues.
细胞定位
Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
功能
function:Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.,tissue specificity:Ubiquitous. Mostly expressed in secretory tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
