产品名称
MK04 Rabbit Polyclonal Antibody
蛋白名称
Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P31152
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P31152/entry
Mouse Swissprot No.
Q6P5G0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6P5G0
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q63454
免疫原
Synthesized peptide derived from human protein . at AA range: 410-490
特异性
MK04 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
组织表达
High expression in heart and brain.
细胞定位
Cytoplasm . Nucleus . Translocates to the cytoplasm following interaction with MAPKAPK5. .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:High expression in heart and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
