产品名称
FHL5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9457
Human Swissprot No.
Q5TD97
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5TD97/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/57756
Mouse Swissprot No.
Q9WTX7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WTX7
Rat Gene Link
https://www.uniprot.org/uniprot/297954
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AXT1
免疫原
Synthesized peptide derived from human FHL5 AA range: 129-179
特异性
This antibody detects endogenous levels of FHL5 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016],
组织表达
Testis-specific (at protein level).
细胞定位
Nucleus . Nuclei of round and elongated spermatids.
功能
function:May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.,similarity:Contains 4 LIM zinc-binding domains.,subcellular location:Nuclei of round and elongated spermatids.,subunit:Interacts with CREM via the third LIM domain.,tissue specificity:Testis-specific (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
