产品名称
IMDH1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3614
Human Swissprot No.
P20839
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P20839/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/23917
Mouse Swissprot No.
P50096
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P50096
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/D3ZLZ7
免疫原
Synthesized peptide derived from human IMDH1 AA range: 304-354
特异性
This antibody detects endogenous levels of IMDH1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],
组织表达
IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
细胞定位
Cytoplasm . Nucleus .
功能
catalytic activity:Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH.,cofactor:Potassium.,disease:Defects in IMPDH1 are the cause of retinitis pigmentosa type 10 (RP10) [MIM:180105]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP10 inheritance is autosomal dominant.,function:Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.,online information:Retina International's Scientific Newsletter,pathway:Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.,similarity:Belongs to the IMPDH/GMPR family.,similarity:Contains 2 CBS domains.,subunit:Homotetramer.,tissue specificity:IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
