产品名称
GFPT1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2673
Human Swissprot No.
Q06210
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q06210/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14583
Mouse Swissprot No.
P47856
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P47856
Rat Gene Link
https://www.uniprot.org/uniprot/297417
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P82808
免疫原
Synthesized peptide derived from human GFPT1 AA range: 198-248
特异性
This antibody detects endogenous levels of GFPT1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008],
组织表达
Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle.
细胞定位
cytosol,extracellular exosome,
功能
catalytic activity:L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.,function:Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.,pathway:Nucleotide-sugar biosynthesis; UDP-N-acetyl-D-glucosamine biosynthesis; D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.,similarity:Contains 1 glutamine amidotransferase type-2 domain.,similarity:Contains 2 SIS domains.,subunit:Homotetramer .,tissue specificity:Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
