产品名称
2AAA Rabbit Polyclonal Antibody
蛋白名称
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P30153
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P30153/entry
Mouse Swissprot No.
Q76MZ3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q76MZ3
免疫原
Synthesized peptide derived from human protein . at AA range: 500-580
特异性
2AAA Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010],
组织表达
Brain,Cajal-Retzius cell,Colon,Placenta,Testis,
细胞定位
Cytoplasm . Nucleus . Chromosome, centromere . Lateral cell membrane . Cell projection, dendrite . Centromeric localization requires the presence of BUB1. .
信号通路
Oocyte meiosis;WNT;WNT-T CELLTGF-beta;Tight junction;Long-term depression;
功能
domain:Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.,function:The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.,similarity:Belongs to the phosphatase 2A regulatory subunit A family.,similarity:Contains 15 HEAT repeats.,subunit:PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
