产品名称
MKRN1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23608
Human Swissprot No.
Q9UHC7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UHC7/entry
Mouse Swissprot No.
Q9QXP6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QXP6
免疫原
Synthesized peptide derived from human MKRN1 AA range: 333-383
特异性
This antibody detects endogenous levels of MKRN1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014],
功能
caution:Could be the product of a pseudogene.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 4 C3H1-type zinc fingers.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
