产品名称
DCK Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1633
Human Swissprot No.
P27707
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P27707/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13178
Mouse Swissprot No.
P43346
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P43346
Rat Gene Link
https://www.uniprot.org/uniprot/79127
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P48769
免疫原
Synthesized peptide derived from human DCK AA range: 62-112
特异性
This antibody detects endogenous levels of DCK at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008],
功能
catalytic activity:NTP + deoxycytidine = NDP + dCMP.,function:Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DCK/DGK family.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
