产品名称
OTOAN Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/146183
Human Swissprot No.
Q7RTW8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q7RTW8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/246190
Mouse Swissprot No.
Q8K561
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K561
免疫原
Synthesized peptide derived from human OTOAN AA range: 1044-1094
特异性
This antibody detects endogenous levels of OTOAN at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
细胞定位
Apical cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side . Secreted, extracellular space, extracellular matrix . At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes. .
功能
disease:Defects in OTOA are the cause of non-syndromic sensorineural deafness autosomal recessive type 22 (DFNB22) [MIM:607039]. DFNB22 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,function:May act as an adhesion molecule.,similarity:Belongs to the stereocilin family.,subcellular location:At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
