产品名称
LOXL4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84171
Human Swissprot No.
Q96JB6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96JB6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67573
Mouse Swissprot No.
Q924C6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q924C6
免疫原
Synthesized peptide derived from human LOXL4 AA range: 39-89
特异性
This antibody detects endogenous levels of LOXL4 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008],
组织表达
Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.
细胞定位
Secreted, extracellular space .
功能
cofactor:Contains 1 lysine tyrosylquinone.,cofactor:Copper.,function:May modulate the formation of a collagenous extracellular matrix.,PTM:The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.,similarity:Belongs to the lysyl oxidase family.,similarity:Contains 4 SRCR domains.,tissue specificity:Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
