产品名称
RT4I1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84816
Human Swissprot No.
Q8WWV3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8WWV3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/170728
Mouse Swissprot No.
Q924D0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q924D0
免疫原
Synthesized peptide derived from human RT4I1 AA range: 282-332
特异性
This antibody detects endogenous levels of RT4I1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, mental retardation, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
组织表达
Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta.
细胞定位
Mitochondrion outer membrane . Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria. .
功能
function:Appears to be a potent inhibitor of regeneration following spinal cord injury.,similarity:Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.,subunit:Interacts with RTN4, UQCRC1 and UQCRC2.,tissue specificity:Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
