产品名称
AP4E1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23431
Human Swissprot No.
Q9UPM8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UPM8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/108011
Mouse Swissprot No.
Q80V94
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80V94
免疫原
Synthesized peptide derived from human AP4E1 AA range: 104-154
特异性
This antibody detects endogenous levels of AP4E1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],
细胞定位
Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein .
功能
function:Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.,similarity:Belongs to the adaptor complexes large subunit family.,subcellular location:Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells.,subunit:Adapter-like complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1).,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
