产品名称
MYH7B Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/57644
Human Swissprot No.
A7E2Y1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/A7E2Y1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/668940
Mouse Swissprot No.
A2AQP0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/A2AQP0
免疫原
Synthesized peptide derived from human MYH7B AA range: 606-656
特异性
This antibody detects endogenous levels of MYH7B at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010],
组织表达
Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver.
细胞定位
Membrane ; Peripheral membrane protein .
功能
caution:This protein sequence has been named 'Slow A' MYH14 (PubMed:11919279), but it also appears also as 'Slow B' MYH15 within the reference.,developmental stage:Found in fetal liver and brain.,function:Involved in muscle contraction.,miscellaneous:Expression does not vary in normal patients compared to patients with acute monocytic leukemia.,miscellaneous:The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.,similarity:Contains 1 IQ domain.,similarity:Contains 1 myosin head-like domain.,subunit:Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).,tissue specificity:Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
