产品名称
NEUR3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
Q9UQ49
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UQ49/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/50877
Mouse Swissprot No.
Q9JMH7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JMH7
Rat Gene Link
https://www.uniprot.org/uniprot/117185
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q99PW5
免疫原
Synthesized peptide derived from human NEUR3 AA range: 132-182
特异性
This antibody detects endogenous levels of NEUR3 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung.
细胞定位
Cell membrane ; Peripheral membrane protein . Membrane, caveola . Early endosome membrane ; Peripheral membrane protein . Recycling endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Associates with the external leaflet of the plasma membrane (By similarity). S-acylated NEU3 likely spans the lipid bilayer with a portion of C-terminus exposed to the cytosol and the catalytic region facing the extracellular space (PubMed:28646141). .
功能
catalytic activity:Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.,function:Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.,similarity:Belongs to the glycosyl hydrolase 33 family.,similarity:Contains 3 BNR repeats.,tissue specificity:Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
