产品名称
PTN4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5775
Human Swissprot No.
P29074
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P29074/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19258
Mouse Swissprot No.
Q9WU22
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WU22
免疫原
Synthesized peptide derived from human PTN4 AA range: 496-546
特异性
This antibody detects endogenous levels of PTN4 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cytoplasm .
功能
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:May act at junctions between the membrane and the cytoskeleton.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
