产品名称
ZPR1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8882
Human Swissprot No.
O75312
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75312/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22687
Mouse Swissprot No.
Q62384
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q62384
免疫原
Synthesized peptide derived from human ZPR1 AA range: 277-327
特异性
This antibody detects endogenous levels of ZPR1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
组织表达
Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients.
细胞定位
Nucleus. Nucleus, nucleolus. Nucleus, gem. Nucleus, Cajal body. Cytoplasm, perinuclear region. Cytoplasm. Cell projection, axon . Cell projection, growth cone . Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons (By similarity). Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner. Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner. .
功能
function:May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus.,similarity:Belongs to the ZPR1 family.,subcellular location:Translocates to the nucleus after treatment with mitogens.,subunit:Binds to the EGF and PDGF receptors. Binds to the elongation factor 1-alpha (By similarity). Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
