产品名称
SNF8 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11267
Human Swissprot No.
Q96H20
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96H20/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/27681
Mouse Swissprot No.
Q9CZ28
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CZ28
Rat Gene Link
https://www.uniprot.org/uniprot/287645
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5RK19
免疫原
Synthesized peptide derived from human SNF8 AA range: 78-128
特异性
This antibody detects endogenous levels of SNF8 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015],
细胞定位
Cytoplasm. Endosome membrane. Nucleus . Late endosome membrane. Recruited to the endosome membrane to participate in vesicle formation.
功能
function:Component of the ESCRT-II complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL.,similarity:Belongs to the SNF8 family.,subunit:Component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 and VPS36/EAP45 (By similarity). Component of the endosomal sorting required for transport complex II (ESCRT-II), composed of SNF8, VPS25 and VPS36. Interacts with TSG101, VPS25 and VPS36.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
