产品名称
S35D2 Rabbit Polyclonal Antibody
基因名称
SLC35D2 HFRC UGTREL8
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11046
Human Swissprot No.
Q76EJ3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q76EJ3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/70484
Mouse Swissprot No.
Q762D5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q762D5
免疫原
Synthesized peptide derived from human S35D2 AA range: 267-317
特异性
This antibody detects endogenous levels of S35D2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008],
组织表达
Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus.
细胞定位
Golgi apparatus membrane ; Multi-pass membrane protein .
功能
function:Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.,similarity:Belongs to the TPT transporter family. SLC35D subfamily.,tissue specificity:Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
