产品名称
ATG3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/64422
Human Swissprot No.
Q9NT62
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NT62/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67841
Mouse Swissprot No.
Q9CPX6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CPX6
Rat Gene Link
https://www.uniprot.org/uniprot/171415
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AZ50
免疫原
Synthesized peptide derived from human ATG3 AA range: 28-78
特异性
This antibody detects endogenous levels of ATG3 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved in autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],
组织表达
Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta.
功能
function:GABARAPL1 (GABARAPL2 or GABARAP or MAP1LC3)-modifier protein conjugating enzyme involved in its E2-like covalent binding to PE. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3 (E2-like enzyme). Preferred substrate is MAP1LC3A. Formation of the GABARAPL1-PE conjugate is essential for autophagy.,similarity:Belongs to the ATG3 family.,subunit:Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.,tissue specificity:Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
