产品名称
CACB1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/782
Human Swissprot No.
Q02641
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q02641/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/12295
Mouse Swissprot No.
Q8R3Z5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R3Z5
Rat Gene Link
https://www.uniprot.org/uniprot/50688
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P54283
免疫原
Synthesized peptide derived from human CACB1 AA range: 79-129
特异性
This antibody detects endogenous levels of CACB1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008],
组织表达
Detected in heart ventricle (at protein level) (PubMed:15615847). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle.
细胞定位
Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein .
功能
function:The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.,similarity:Belongs to the calcium channel beta subunit family.,similarity:Contains 1 SH3 domain.,subunit:The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with JSRP1.,tissue specificity:Expressed in brain, heart and spleen (isoform 1 and 3) and in skeletal muscle (isoform 2).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
