产品名称
TWF1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5756
Human Swissprot No.
Q12792
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q12792/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19230
Mouse Swissprot No.
Q91YR1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91YR1
Rat Gene Link
https://www.uniprot.org/uniprot/315265
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5RJR2
免疫原
Synthesized peptide derived from human TWF1 AA range: 179-229
特异性
This antibody detects endogenous levels of TWF1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008],
组织表达
Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton . Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). .
功能
caution:Was originally (PubMed:7507208) thought to have protein tyrosine kinase activity.,function:Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.,online information:Molecular embrace -Issue 73 of August 2006,PTM:Phosphorylated on serine and threonine residues.,similarity:Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.,similarity:Contains 2 ADF-H domains.,subcellular location:Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts.,subunit:Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated.,tissue specificity:Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
