产品名称
INT3 Rabbit Polyclonal Antibody
基因名称
INTS3 C1orf193 C1orf60
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/65123
Human Swissprot No.
Q68E01
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q68E01/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/229543
Mouse Swissprot No.
Q7TPD0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TPD0
免疫原
Synthesized peptide derived from human INT3 AA range: 417-467
特异性
This antibody detects endogenous levels of INT3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016],
细胞定位
Nucleus . Cytoplasm . Localizes to nuclear foci following DNA damage.
功能
function:Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.,sequence caution:Intron retention.,similarity:Belongs to the Integrator subunit 3 family.,subunit:Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
