产品名称
SRGN Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5552
Human Swissprot No.
P10124
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P10124/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/19073
Mouse Swissprot No.
P13609
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P13609
Rat Gene Link
https://www.uniprot.org/uniprot/56782
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P04917
免疫原
Synthesized peptide derived from human SRGN AA range: 30-80
特异性
This antibody detects endogenous levels of SRGN at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010],
细胞定位
Cytoplasmic granule . Cytolytic granule . Secreted, extracellular space . Golgi apparatus . Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation (By similarity). Secreted constitutively by endothelial cells and macrophages (PubMed:11154222). Located to Golgi apparatus during neutrophil differentiation (PubMed:15136585). .
功能
function:Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.,induction:By EBV.,PTM:O-glcosylated; contains chondroitin sulfate and heparan sulfate.,similarity:Belongs to the serglycin family.,subcellular location:Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.,subunit:Binds to activated CD44 and to GZMB.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
