产品名称
DAZL Rabbit Polyclonal Antibody
基因名称
DAZL DAZH DAZL1 DAZLA SPGYLA
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1618
Human Swissprot No.
Q92904
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92904/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13164
Mouse Swissprot No.
Q64368
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q64368
免疫原
Synthesized peptide derived from human DAZL AA range: 202-252
特异性
This antibody detects endogenous levels of DAZL at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
细胞定位
Cytoplasm . Nucleus . Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward. .
功能
disease:Defects in DAZL may be a cause of infertility due to severe oligozoospermia (AZ) and non obstructive azoospermia.,domain:The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2.,function:RNA-binding protein, which is essential for gametogenesis. Plays a central role during spermatogenesis. May act by binding to the 3'-UTR of mRNA and thereby regulating the translation of key transcripts.,similarity:Belongs to the RRM DAZ family.,similarity:Contains 1 DAZ-like domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subcellular location:Predominantly cytoplasmic (By similarity). Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward.,subunit:Homodimer and heterodimer (By similarity). Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2.,tissue specificity:Testis specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
