产品名称
FOXN1 Rabbit Polyclonal Antibody
蛋白名称
Forkhead box protein N1 (Winged-helix transcription factor nude)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O15353
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15353/entry
Mouse Swissprot No.
Q61575
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61575
免疫原
Synthesized peptide derived from human protein . at AA range: 340-420
特异性
FOXN1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008],
组织表达
Expressed in thymus.
功能
disease:Defects in FOXN1 are the cause of T-cell immunodeficiency congenital alopecia and nail dystrophy [MIM:601705].,function:Transcriptional regulator involved in development.,online information:FOXN1 mutation db,similarity:Contains 1 fork-head DNA-binding domain.,tissue specificity:Expressed in thymus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
