产品名称
TBCD Rabbit Polyclonal Antibody
基因名称
TBCD KIAA0988 SSD1 TFCD PP1096
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6904
Human Swissprot No.
Q9BTW9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BTW9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/108903
Mouse Swissprot No.
Q8BYA0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BYA0
免疫原
Synthesized peptide derived from human TBCD AA range: 419-469
特异性
This antibody detects endogenous levels of TBCD at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitously expressed.
细胞定位
Cell junction, tight junction . Lateral cell membrane . Cytoplasm . Cell junction, adherens junction . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localized in cell-cell contacts. .
功能
function:Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB).,induction:Down-regulated by shear stress.,similarity:Belongs to the TBCD family.,similarity:Contains 3 HEAT repeats.,subunit:Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
