产品名称
ITM2C Rabbit Polyclonal Antibody
基因名称
ITM2C BRI3 hucep-14 NPD018 PSEC0047
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/81618
Human Swissprot No.
Q9NQX7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NQX7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/64294
Mouse Swissprot No.
Q91VK4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91VK4
Rat Gene Link
https://www.uniprot.org/uniprot/301575
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5PQL7
免疫原
Synthesized peptide derived from human ITM2C AA range: 1-51
特异性
This antibody detects endogenous levels of ITM2C at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
组织表达
High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.
细胞定位
Lysosome membrane ; Single-pass type II membrane protein . Cell membrane ; Single-pass type II membrane protein .
功能
PTM:Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C.,similarity:Belongs to the ITM2 family.,similarity:Contains 1 BRICHOS domain.,subunit:Interacts with BACE1.,tissue specificity:High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.